The API-FDF spread is the conversion-margin lens. PharmaDB joins API and FDF aggregates at the molecule key, computes the embedded API cost per pack, and returns the residual as the observable conversion margin. Refresh cadence is weekly.
Compute the observable market spread between API bulk cost and FDF selling price per molecule. The empirical basis for conversion-margin and make-vs-buy decisions.
Palbociclib API clears at $6,263/kg median across 10 suppliers and 62 shipments; the 125mg / 21-cap FDF pack clears at $21.54 median across 24 shipments. The conversion math: 2.625g of API per pack, so $16.44 of API cost is embedded in each $21.54 pack at median price. The observable spread is $5.10 per pack, or 24% of the FDF price. That spread covers excipients, formulation overhead, packaging, regulatory amortisation, and margin. Tight.
Type the molecule INN. The AI agent pulls the API global price percentile and every FDF form-strength-pack combination with declared shipments.
API USD/kg is converted to embedded API cost per pack using the form-strength-pack composition. The FDF median price minus the embedded API cost equals the observable conversion spread.
Citation-anchored brief with the API band, the FDF band, the embedded API cost per pack, and the conversion margin as both a dollar value and a percentage.
Two separate clearance distributions, normalised to the same molecule. The conversion math is exact at the form-strength-pack level; no industry rule of thumb.
If the embedded API cost exceeds 80% of the FDF price, the conversion margin is too thin to support in-house manufacturing; toll-manufacture or out-source. The brief surfaces the threshold automatically.
Each combo carries a shipment count. Combos with fewer than 10 shipments are flagged low-confidence; the headline spread uses the highest-volume combo as the anchor.
API and FDF aggregates refresh weekly. The spread reruns on every refresh; the brief carries the exact computation timestamp.
A real chat thread in PharmaDB. Type a question, the AI agent runs the tools, the answer lands as a saveable note.
pharmagraph_query Eleven molecules · 2024 API median vs FDF median pack price · spread computed at the highest-volume FDF combination.
The API-FDF spread is the conversion-margin lens. PharmaDB joins API and FDF aggregates at the molecule key, computes the embedded API cost per pack, and returns the residual as the observable conversion margin. Refresh cadence is weekly.
API USD/kg times the active-ingredient mass per pack. For palbociclib 125mg x 21 capsules, the API mass per pack is 125mg x 21 = 2.625g, embedding $16.44 of API at the $6,263/kg median. The same math applies to every form-strength-pack combination on the molecule.
Same combo with two clusters (one near branded price, one near generic price) is surfaced as two rows. The headline spread uses the higher-volume row; the alternative cluster is reported below the headline with its own shipment count and spread.
Oncology FDF prices are anchored to generic-entry pricing while the API is still concentrated (10 suppliers). The conversion economics are thin until either API competition deepens (driving the embedded cost down) or the FDF moves into specialty-pricing tiers.
Yes. If the embedded API cost is above 80% of the FDF price, the conversion margin is too thin to support in-house manufacturing at typical overhead. The brief flags the threshold automatically.
Not separately. The conversion spread is the residual: FDF price minus embedded API cost. Excipients, packaging, regulatory amortisation, and margin all live in that residual. The reader applies their own cost structure to allocate.
API and FDF aggregates both refresh weekly. The spread recomputes on every refresh; the catalog row carries the exact timestamp.
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